The diocese of Konongo‑Mampong was created on 3 March 1995 by His Holiness Pope John Paul II. It was carved out of two other dioceses, namely the diocese of Kumasi and the diocese of Sunyani. About 90% of the territory of the new diocese of Konongo- Mampong belonged to the diocese of Kumasi, which was created in 1950, having existed as a Vicariate for 18 years. The rest of the territory of the diocese belonged to the Sunyani diocese. Most Rev. Joseph Osei-Bonsu is the first Bishop of Konongo-Mampong. He was ordained bishop and installed on 28 May and 11 June, 1995 respectively.
Mampong is traditionally and historically second in importance to the Asante capital, Kumasi. Konongo is the oldest church in the diocese, its origins going back to 1917. It seems that it was for these reasons that Rome named the new diocese the “Konongo-Mampong Diocese”.
On 28 December 2007 the Diocese of Techiman was erected from the Sunyani and Konongo-Mampong Dioceses. The following parishes were taken from Konongo-Mampong and given to the new diocese of Techiman: Yeji, Atebubu, Kwame Danso and Prang.
Governance
The diocese has established or constituted certain councils, commissions and committees to assist the Bishop in governing the entire diocese. The table below gives their composition and key functions.
| Council / Commission / Committee | Key Function | Nature of Body |
| College of Consultors | Bishop consults them before on policies are made. | Consultative |
| Priests’ Council (Senate) | ||
| Diocesan Pastoral Council | Forum to study, weigh and make suggestions on diocesan policy proposals. | |
| Diocesan Finance Council | To deliberate and prepare financial policy proposals. | Deliberative and Policy Formulating |
| Diocesan Pastoral Coordinating Council | To harmonize the work of diocesan pastoral agencies and prepare policy proposals. | |
| Diocesan Development Commission | To harmonize physical and socio-economic development interventions and prepare policy proposals | |
| Diocesan Building and Projects Committee | To monitor the preparation and implementation of projects |
Coordination
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| Diocesan Education Committee | To deliberate and provide technical advice on formal educational issues. | |
| Diocesan Health Committee | To coordinate the work of diocesan health institutions. | |
| Development Fund Management Committee | To manage the development fund. | |
| Diocesan Laity Council | To coordinate the work of lay societies and associations. | |
| Diocesan Women’s Council | To coordinate the work of solely women’s movements | |
| Diocesan Youth Council | To coordinate the work of youth associations. |